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Test Code PAPP-A PREG ASSOC PLASMA PROTEIN-A

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Useful for prenatal screening for neural tube defect and Down syndrome when performed in conjunction with AFP QUAD “Alpha-Fetoprotein (AFP) Quad Test, Serum” as part of a maternal serum integrated screen. The PAPP-A must be performed between 10 and 13 weeks, and the AFP QUAD must be performed between 15 and 22 weeks. (AFP QUAD includes AFP, chorionic gonadotropin, estriol, and inhibin-A).

Specimen Requirements

Container/Tube: Plain, red-top tube(s) or serum gel tube(s)
Specimen Volume: 5 mL (minimum volume: 1 mL) of maternal serum

Collection Instructions:

Note: 1. Gestational age must be between 10 and 13 weeks (10 to 11 weeks is optimal).

2. Ultrasound dating of pregnancy is preferred.

Forms: “Shodair Children’s Hospital Expanded Maternal Serum Screening Requisition”

See “Requisitions” in Special Instructions for a copy of the form.

Day(s) Test Set Up

Monday through Sunday

Reference Values

One interpretive report for both PAPP-A and AFP QUAD will be provided after both tests have been performed.

Performing Laboratory

Women and Infants Hospital

Test Classification and CPT Coding

84163

Specimen Transport Temperature

Refrigerate/Frozen NO

Special Instructions