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Test Code MATERNIT21 MaterniT21

Important Note

Test should only be drawn Sunday-Thursday.  It may be drawn Friday if it is submitted to the Send-Out Lab by 12:00.  Do not draw around a holiday.  Tests should be sent out the day they are drawn, but may be sent out the next day.  Specimens are stable for 72 hours.

Methodology

MaterniT21 is a laboratory-developed blood test that is noninvasive and available for women with increased risk indicators for fetal chromosomal abnormalities. This test analyzes circulating cell-free DNA extracted from a maternal blood sample.  It detects the relative amount of 21, 18, 13, and Y chromosomal material. 

 

Circulating cell-free DNA is purified from the plasma component of anti-coagulated maternal whole blood.  The DNA is analyzed for autosomal and Y chromosomal material and converted into a genomic DNA library for the determination of chromosome 21, 18, 13, and Y representation based on massively parallel DNA sequencing.  This test may be performed as early as 10 weeks gestation.

Specimen Requirements

Container/Tube: Special Kit in Send-Outs (green)

Specimen Volume: 20mL whole blood

Collection Instructions: Use special kit in Send-Outs and submit the same day as collection. Specimen stable for 72 hours. 

NOTE: Short draws or specimens <10 weeks gestation may lead to unreportable results. 

Test should only be drawn Sunday-Thursday.  It may be drawn Friday if it is submitted to the Send-Out Lab by 12:00.  Do not draw around a holiday.  Tests should be sent out the day they are drawn, but may be sent out the next day.  Specimens are stable for 72 hours. 

           

Day(s) Test Set Up

Monday through Friday

Reference Values

An interpretative report will be provided to the ordering physician by Sequenom.

Performing Laboratory

Sequenom

Specimen Transport Temperature

Ambient/Frozen NO