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Test Code JCV JC Virus Detection by In Situ Hybridization


Shipping Instructions


Attach the green pathology address label included in the kit to the outside of the transport container.



Necessary Information


A pathology/diagnostic report and a brief history are required.



Specimen Required


Specimen Type: Formalin-fixed, paraffin-embedded tissue block

Supplies: Pathology Packaging Kit (T554)

Specimen Volume: Entire block

 

Specimen Type: Slides

Slides: 4 Unstained glass, positively-charged slides with 5 (+ or - 1)-microns formalin-fixed, paraffin-embedded tissue


Useful For

Confirming a clinical and histopathologic diagnosis of progressive multifocal leukoencephalopathy

Method Name

In Situ Hybridization (ISH)

Reporting Name

JC Virus ISH

Specimen Type

Special

Specimen Stability Information

Specimen Type Temperature Time Special Container
Special Ambient (preferred)
  Refrigerated 

Reject Due To

Wet/frozen tissue
Cytology smears
Nonformalin fixed tissue
Nonparaffin embedded tissue
Noncharged slides
ProbeOn slides		 Reject

Clinical Information

JC virus is the etiologic agent of progressive multifocal leukoencephalopathy (PML), a rare, demyelinating, fatal disorder of the central nervous system that occurs on a background of immune deficiency. PML is an infrequent complication of a wide variety of conditions, including lymphoproliferative disorders (Hodgkin disease, chronic lymphocytic leukemia), sarcoidosis, tuberculosis, and AIDS.

Interpretation

This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation or analysis is needed, request PATHC / Pathology Consultation along with this test.

Cautions

Studies have shown potential cross reactivity between polyoma (BK) and JC virus in situ hybridization (ISH) testing.(1)

 

Age of a cut paraffin section can affect staining quality. Stability thresholds vary widely among published literature. Best practice is for paraffin sections to be cut within 6 weeks.

Day(s) Performed

Monday through Friday

Report Available

5 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88365-Primary

88364-If additional ISH

LOINC Code Information

Test ID Test Order Name Order LOINC Value
JCV JC Virus ISH In Process

 

Result ID Test Result Name Result LOINC Value
71214 Interpretation 50595-8
71215 Participated in the Interpretation No LOINC Needed
71216 Report electronically signed by 19139-5
71218 Material Received 81178-6
71596 Disclaimer 62364-5
72115 Case Number 80398-1

Forms

If not ordering electronically, complete, print, and send an Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763) with the specimen.