Sign in →

Test Code BTBAS Butabarbital, Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions:

1. Draw blood immediately before the next scheduled dose.

2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.


Useful For

Monitoring of butabarbital therapy

Method Name

Gas Chromatography Mass Spectrometry (GC-MS)

Reporting Name

Butabarbital, S

Specimen Type

Serum Red

Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Clinical Information

Butabarbital is a short to intermediate acting barbiturate derivative that is US Food and Drug Administration-approved for use in insomnia, in preoperative sedation, and as a hypnotic agent. Butabarbital is extensively metabolized and eliminated primarily by renal excretion. The elimination half-life ranges from 34 to 100 hours.

Reference Values

Therapeutic range:

2.0-3.0 mcg/mL Hypnosis

25 mcg/mL Sedation/Sleep

>30 mcg/mL Coma

Toxic concentration: >50 mcg/mL

 

Cutoff concentrations by gas chromatography mass spectrometry:

Butabarbital: 0.5 ng/mL

Interpretation

Butabarbital concentrations between 2.0 and 3.0 mcg/mL have been used for hypnosis/sedation with concentrations up to 25 mcg/mL used for sleep. Toxic concentrations have been reported as greater than 50 mcg/mL.

Cautions

The concentration at which toxicity occurs varies, and results should be interpreted in light of the clinical situation.

 

Specimens collected in serum gel tubes are not acceptable because the drug can absorb on the gel and lead to falsely decreased concentrations.

Day(s) Performed

Thursday

Report Available

3 to 9 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BTBAS Butabarbital, S 16236-2

 

Result ID Test Result Name Result LOINC Value
622885 Butabarbital, S 16236-2