Home
HelpTest Code B2MC Beta-2-Microglobulin (Beta-2-M), Spinal Fluid
Reporting Name
Beta-2-Microglobulin, CSFUseful For
Evaluation of central nervous system inflammation and B-cell proliferative diseases
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
CSFSpecimen Required
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions: Send spinal fluid from collection vial 1.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 14 days |
Reference Values
0.70-1.80 mcg/mL
Day(s) Performed
Monday through Friday
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82232
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| B2MC | Beta-2-Microglobulin, CSF | 1951-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| B2MC | Beta-2-Microglobulin, CSF | 1951-3 |
Clinical Information
Beta-2-microglobulin (beta-2-M) is a small membrane protein (11,800 Da) associated with the heavy chains of class I major histocompatibility complex proteins and is, therefore, on the surface of all nucleated cells. The small size allows beta-2-M to pass through the glomerular membrane, but it is almost completely reabsorbed in the proximal tubules.
Increased beta-2-M levels in the cerebrospinal fluid (CSF) have been shown to be of diagnostic use in non-Hodgkin lymphoma with central nervous system involvement. Elevated CSF:serum ratios seen in patients with aseptic meningoencephalitis suggest the possibility of neurologic processes including those associated with HIV infection and acute lymphoblastic leukemia. Beta-2-M measurement in multiple sclerosis seems to be of indeterminate usefulness.
Interpretation
Elevations of cerebrospinal fluid beta-2-microgobulin levels may be seen in a number of diseases including malignancies, autoimmune disease, and neurological disorders.
Cautions
Results determined by assays using different manufacturers or methods may not be comparable.
Report Available
1 to 3 daysReject Due To
| Gross hemolysis | OK |
Method Name
Nephelometry